Endoscopic submucosal dissection (ESD) allows for en bloc resection of large superficial neoplasms of the GI tract. However, ESD of lesions involving the appendix has a high risk of adverse events, even for experts.1-3 Endoscopic full-thickness resection (EFTR) using a full-thickness resection device (FTRD; Ovesco Endoscopy, Tübingen, Germany) is a new approach for these lesions, but the main limitation is tumor size.4-6 A recent case series described the hybrid ESD-EFTR technique as a rescue approach for “difficult” ESD (Fig. 1).