A 72-year-old man was detected as having a flat-elevated tumor located in the appendix, measuring 15 mm in diameter (Fig. 1A). The lesion completely covered the appendiceal orifice, and the edge of the lesion could not be visualized (Fig. 1B). Because patients usually want minimally invasive treatments, endoscopic transcecal appendectomy was scheduled after the patient provided informed consent. It is our strategy to use a single port to introduce the laparoscope and confirm the condition around the appendix, to guide the endoscope safely, and to endoscopically resect the lesion and close the defect.