Inadequate bowel preparation for a colonoscopy can occur in more than 25% of cases.1 This is associated with increased patient cost because of the need for additional examinations, reduced diagnostic yield, and increased risk of interval colorectal cancer.2,3 A recently developed, novel overtube (OT) device (IzoScope; IzoMed Inc, Irvine, Calif, USA) can safely and efficiently seal a compartment of the colon to administer targeted fluid lavage (eg, right colonic enema). We performed a proof-of-concept study using a single domestic pig to describe the use of this device to address segmental suboptimal bowel preparation and improve visibility during colonoscopy (Video 1, available online at www.giejournal.org ).