Although radiofrequency ablation (RFA) has been well described in the treatment of Barrett’s esophagus with dysplasia by inducing local thermal necrosis, its role through the use of EUS has garnered considerable interest over the past few years, particularly with pancreatic cysts and tumors. Although surgery remains the mainstay for solid pancreatic neoplasms, EUS-guided RFA offers a safe and effective treatment option in patients deemed unfit for, or who do not wish to undergo, surgery.1-4 Here, we present a case of an 82-year-old woman with osteoarthritis who presented with progressively worsening upper-abdominal pain over the past month and accompanying weight loss.