Cancer immunotherapy with the use of checkpoint inhibitors, ipilimumab (anti-cytotoxic T lymphocyte antigen) or nivolumab, pembrolizumab, and atezolizumab (anti-programmed death-1) may induce colitis, an increasingly recognized immune-mediated adverse event (IrAE). The spectrum of endoscopic findings at colonoscopy has not been defined comprehensively; Crohn’s-like and ulcerative colitis–like changes have been described.1,2 Colitis is most commonly described, although ileoscopy is not always conducted.