Volumetric laser endomicroscopy (VLE) (Ninepoint Medical, Bedford, Mass, USA) is a balloon-based second-generation optical coherence tomography technology that provides high-resolution esophageal imaging.1-4 The novel algorithm of computer-enhanced visualization (intelligent real-time image segmentation, IRIS) of VLE highlights features previously associated with suspected dysplasia, including hyperreflective tissue surface signal (pink) and hyporeflective cystic structures above the submucosal layer (blue).