GI transmural defects may be classified into 3 distinct categories: perforations, leaks, and fistulas. Each represents a therapeutic challenge directly affecting morbidity, mortality, and quality of life and is associated with significant healthcare costs.1,2 Endoscopic therapy has become the first-line therapy in most cases,3,4 with available treatment modalities that include closure techniques such as glues/tissue sealants, cap-mounted clips, and endoscopic suturing; cover techniques such as self-expandable metal stents (SEMSs) and cardiac septal defect occluder devices; and endoscopic draining approaches such as septotomy, endoscopic internal drainage with double-pigtail stents, and endoscopic vacuum therapy (EVT).