Pancreatic duct cannulation in chronic pancreatitis fails in up to 10% to 30% of cases because of difficult guidewire or catheter manipulation.1 Synthetic porcine secretin2 and more challenging techniques such as EUS-guided drainage or dorsal duct cannulation have been proposed.1-3 Pancreatic guidewire-assisted biliary cannulation, also known as the double-guidewire (DGW) technique, after failure of deep cannulation of the common bile duct (CBD) was first described in 1998 by Dumonceau et al.3,4 The aim of the DGW technique is to obstruct the pancreatic orifice and facilitate deep biliary cannulation.