Duodenal adenoma has a risk of developing into cancer. En bloc resection with conventional EMR is difficult for a large lesion, whereas duodenal endoscopic submucosal dissection is associated with a high risk of perforation.1 Piecemeal underwater EMR is effective for large duodenal adenomas; however, a large mucosal defect carries a risk of delayed adverse events.2 Although complete closure after endoscopic resection can reduce adverse events,3,4 closure of a large mucosal defect with endoclips is difficult.