Endoscopic full-thickness resection (EFTR) is used to achieve R0 resection and comes from the need to overcome the limitations of endoscopic submucosal dissection in the management of lesions arising from, or infiltrating, the muscularis propria (subepithelial tumor) and of nonlifting or partially treated lesions.1 Several techniques have been developed over time.2,3 Initially, exposed techniques, which consist of creating an open wound followed by secure closure, were investigated. These techniques include submucosal tunneling with endoscopic resection,4,5 endoscopic submucosal excavation,6 and endoscopic full-thickness resection with secondary closure (exposed EFTR).