Afferent limb syndrome can occur from benign and malignant causes, leading to biliary obstruction and cholangitis.1 Patients are often managed with long-term percutaneous biliary drains, which are associated with pain, obstructions, dislodgements, leakage, and chronic biliocutaneous fistulas.2 Although acute leaks around hepaticojejunal anastomoses are not uncommon, chronic anastomotic dehiscence is very rare but can lead to abscess formation and subsequent fistulization.3 In patients who are deemed poor surgical candidates, can these conditions be treated endoscopically? (Institutional review board approval was obtained for this study.)