Nonsurgical candidates with acute cholecystitis are traditionally treated by percutaneous transhepatic or transperitoneal gallbladder drainage that achieves clinical response rates ranging from 56% to 100%.1,2 These approaches, however, may be associated with adverse events, including bleeding and postprocedural infections, in up to 65% of cirrhotic patients. In addition, percutaneous tube placemement may result in patient dissatisfaction, discomfort, and risk of tube dislodgment.3 With the advent of novel endoscopic tools and techniques, internal gallbladder drainage has become an alternative for nonsurgical patients with acute cholecystitis.