Intraductal papillary neoplasm of the bile duct (IPNB) is a rare disease that is characterized by papillary or villous neoplasm within the lumen of the bile duct.1 IPNB can develop anywhere along the biliary tree.2 In principle, aggressive resection is recommended as the first choice. However, hepatectomy is too aggressive for small localized tumors without significant invasion. Here, we report a case of a small hilar IPNB that was diagnosed using a digital cholangioscope (SpyGlass, Boston Scientific, Marlborough, Mass) and treated by cholangioscopy-guided photodynamic therapy (PDT) (Guoyi Huake, Suzhou, China).