Endoscopic full-thickness resection (EFTR) is increasingly performed for the removal of GI subepithelial lesions (SELs). EFTR is minimally invasive compared with surgery but still can procure an adequate specimen for histologic assessment. A dedicated EFTR device (Ovesco Endoscopy, Tübingen, Germany) has been developed for the management of colorectal lesions.1 Data on its safety and efficacy for lesions in the upper GI tract are limited.2,3 In this case, we share our experience with the off-label use of a dedicated EFTR device for the removal of a GI stromal tumor (GIST) in the stomach.