Recently, endoscopic submucosal dissection (ESD) has been applied to the treatment of GI lesions to enable en bloc curative resection.1,2 Generally, large tumor size, protruded lesion, poor endoscope maneuverability, and other procedural factors may contribute to the technical difficulties of ESD and periprocedural perforation.3,4 Among ESD procedures for GI lesions, duodenal ESD is the most technically challenging procedure because of the thin wall and narrow lumen of the duodenum, as well as poor maneuverability of the endoscope in the duodenum.