A 61-year-old otherwise healthy man was referred to us for further evaluation of multiple firm, large, subepithelial descending colonic nodules. The area of nodularity was found incidentally on a screening colonoscopy and was located in the descending colon near the splenic flexure. The nodules extended over a length of 5 cm and varied in size from 1 cm to 2.5 cm. One nodule was sampled several times; however, examination of biopsy specimens revealed only colonic mucosa with inflammation and architectural distortion.