GI lipomas are rare, benign, submucosal tumors that are usually asymptomatic. The most common location for these lesions is the colon (64%), whereas duodenal lipomas account for only 4% of GI lipomas.1 Large lipomas (>2-4 cm) may cause symptoms such as bleeding, abdominal pain, obstruction, or intussusception.1-16 They typically present as a smooth, slightly yellow, rounded polyp, with a stalk or a broad-based attachment. Diagnosis can be confirmed by EUS, CT scan, or magnetic resonance imaging.