The progress of endoscopic therapy in the upper GI tract is limited by the size of the endoscope working channel and by the need to achieve triangulation for instrumentation. A novel transgastric trocar (Endoscopic Trans-Abdominal Gastric Surgery System [Endo-TAGSS, LLC, Shawnee, Kansas, USA]; Kansas City, Mo, USA) has been developed to allow intraluminal therapy using a combined endoscopic and laparoscopic approach (Fig. 1).1,2 The device, not yet Food and Drug Administration approved, is deployed under endoscopic vision with a technique similar to a pull PEG (Fig. 2), and it has been shown to be safe in a preclinical study that evaluated tract closure upon trocar withdrawal.