Joseph B. Kirsner, MD, PhD, devoted his life to the art and science of medicine, establishing, and then leading, the section of Gastroenterology, Hepatology, and Nutrition at the University of Chicago Medicine for over 80 years. That section has been credited as being the first academic GI unit in the world. He served as a mentor to generations of physicians and established a legacy of practical wisdom, personal integrity, rigorous scientific inquiry, and unequaled patient care (Author photos 1-11, Video 1 available online at www.VideoGIE.org ).